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Title   유방암의 예후에 대한 DNA topoisomerase II와 P-당단백 발현의 유용성 ( Expression of DNA Topoisomerase II and P=Glycopretein in Breast Cancer )
Publicationinfo   1997 Jan; 029(02): 243-250.
Key_word   DNA topoisomerase II, P-glycoprotein, Breast cancer, Immunohistochemistry
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Abstract   Purpose: To determine whether the expression of DNA topoisomerase II and P-glycoprotein are of prognostic value. Materials and Methods: We evaluated the expression of DNA topoisomerase II and P-glycoprotein immunohistochemically in a retrospective study of samples from 44 patients with breast cancer. Thirty two among 44 patients (72.7%) received chemotherapeutic treatments (CMF or FAC protocol) and/or tamoxifen postoperatively. Results: P-glycoprotein was detected in the 27 samples of 44 patients (61.3%). The expression of P-glycoprotein was increased in the patients older than 50 years, with distant metastases, and with death on follow-up. DNA topoisomerase II was detected in the 34 samples of 44 patients (77.2%). The expression of topoisomerase II was increased in the patients younger than 50 years, with recurrent tumor, with distant metastases, and with death on follow-up. The expression of P-glycoprotein and topoisomerase II was not correlated with other clinico-pathological factors including the size of primary tumor, involvement of lymph node, histologic grade, and clinical stage. The correlation between expression of P-glycoprotein and topoisomerase II was not significant. Conclusion: The immunohistochemical evaluation of P-glycoprotein and topoisomerase II before treatment in breast cancer has little clinical prognostic value.
저 자   박혜림(Hye Rim Park),정은하(Eun Ha Jung),손진희(Jin Hee Son),박영의(Young Ei Park)